Browsing Technological University of the Shannon: Midlands Midwest by Subject "Drug delivery systems"
Now showing items 1-19 of 19
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Antimicrobial films containing green synthesised zinc oxide nanoparticles for biomedical applications
(Athlone Institute of Technology, 2020-06)Synthetic biomaterials have been vastly investigated for different biomedical applications such as wound healing adhesives, implant devices and drug delivery systems. The effort on this field of study promoted the ... -
Composite cryogels for dual drug delivery and enhanced mechanical properties.
(Wiley, 2018-04)In this study, we present a simple and effective process that integrates hydrogels with drugs + ceramics via physical crosslinks resulting in improved mechanical properties. These cryogels have the potential for controlled ... -
Development of biphasic drug delivery PVA/propolis electrospun nanofibres
(Athlone Institute of Technology, 2020-06)The integration of nanotechnology into biomedical applications is called “nanomedicine”. Nanomedicine has the ability to change properties of materials at the molecular and atomic level [1]. Numerous methods have been ... -
Development of novel monolithic matrices for drug delivery using conventional and non-conventional polymer processing technologies.
(2007)The aim of this study was to produce a range of polymer based monolithic matrices for controlled oral drug delivery using conventional polymer processing equipment. Poly (ethylene oxide) (PEO) was chosen as the primary ... -
The development of novel polymeric delivery systems for the controlled release of therapeutic agents to prevent the spread of zoonotic diseases
(2022)The potential for zoonotic transmission - a disease transmitted from animals to people - of many disease pathogens is a significant concern worldwide. It is estimated that 60 of human emerging infectious diseases, including ... -
The development of novel PVA hydrogel for biomedical and drug delivery applications
(Athlone Institute of Technology, 2021-08)Hydrogels have been used widely in biomaterial applications, mainly due to their low interfacial tension, useful swelling properties and high lubricity. In addition to their promising biocompatibility characteristics, ... -
Development of novel PVA-based nanoparticles for delivery system for bone cancer applications
(Athlone Institute of Technology, 2020-06)Osteosarcoma is one of the most frequent bone cancers with almost 30% of patients developin metastasis [1,2]. Further study is needed to develop new drugs that avoid metastasis. There is experimental evidence that chalcones, ... -
Enhancing drug solubility through advanced polymer extruded shellac-based matrix drug delivery systems
(Technological University of the Shannon: Midlands Midwest, 2022-09)The main objective of this study is to enhance the solubility of the model drug fenofibrate, by forming amorphous solid dispersions using a hot melt extrusion process. Hot melt extrusion offers an efficient way of ... -
Faster release of lumen-loaded drugs than matrix-loaded equivalent in polylactic acid/halloysite nanotubes.
(MDPI, 2019-06-15)Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based ... -
Investigation of a novel freeze-thaw process for the production of drug delivery hydrogels
(Springer, 2005-12)Poly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising ... -
Investigation of the effects of orientation on freeze/thawed Polyvinyl alcohol hydrogel properties.
(Elsevier, 2018-12)Although hydrogels produced via freeze-thawing (F/T) technique have been thoroughly studied in literature, stretching hydrogels in between freeze-thawing cycles could change its properties and might be modulated for drug ... -
Micro-injection moulding of poly(vinylpyrrolidone-vinyl acetate) binary and ternary amorphous solid dispersions.
(MDPI, 2019-05)Micro-injection moulding (µIM) was used for the production of enteric tablets of plasticised and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect of the mechanical and thermal ... -
"My heart, your heart"; hot melt enteric targeted therapeutic delivery platform: enhancing drug solubility through advanced polymer extruded drug delivery system
(Athlone Institute of Technology, 2020-06)Cardiovascular diseases (CVDs) are the number 1 cause of death globally. Fenofibrate has been shown an excellent treating effect on CVDs. However, Fenofibrate is a neutral, lipophilic compound that is practically insoluble ... -
Novel polyvinyl-alcohol microsphere for everolimus delivery for subependymal cell astrocytoma
(Elsevier, 2023-02-02)Everolimus (EVR) has demonstrated efficacy in treating subependymal giant cell astrocytoma (SEGA) and other tuberous sclerosis (TSC) manifestations. Oral use of EVR is associated with low bioavailability and systemic toxicities ... -
Preparation of a novel freeze thawed poly (vinly alcohol) composite hydrogel for drug delivery applications
(Elsevier, 2007-09)Poly(vinyl alcohol) (PVA) is a water-soluble, biocompatible and biodegradable polymer, which has been widely applied in biomedical fields. In this paper, novel physically cross-linked hydrogels composed of PVA and comprising ... -
Processing stability and the significance of variation in extrusion speeds and temperture on SSB® 55 Pharma Grade Shellac for Oral Drug Delivery
(MDPI, 2017-09-06)The melt-extrusion process is utilized in the pharmaceutical arena for the manufacturing of a variety of dosage forms and formulations, including solid dispersions. This technology is considered an efficient and continuous ... -
The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.
(IOP Science, 2019-06-05)Although freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric network arrangement ... -
Smart hydrogels: therapeutic advancements in hydrogel technology for smart drug delivery applications.
(Wiley, 2015-12)Hydrogels are a fusion of solid and liquid phases which closely mimic biological tissue. As such they have enormous potential for drug delivery systems as they are biocompatible and may be tailored to specific applications. ... -
Synthesis and characterisation of novel temperature and pH sensitive physically crosslinked poly(N-vinylcaprolactam-co-itaconic acid) hydrogels for drug delivery.
(MDPI, 2019-08-29)Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this ...