Browsing Technological University of the Shannon: Midlands Midwest by Author "Reidy, Sean"
Now showing items 1-5 of 5
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Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
Dillon, Gerald P.; Gaynor, Joanne M.; Khan, Denise; Carolan, Ciaran G.; Ryder, Sheila A.; Marquez, Juan F.; Reidy, Sean; Gilmer, John F. (Elsevier, 2010-02-01)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Laccase oxidation studies: method development for following the benzyl alcohol oxidation reaction using the Laccase/TEMPO system
Gan, Hong Ann; Reidy, Sean; Morris, Noreen; Selver, Luc; Moody, Tom (Technological University of the Shannon Midlands Midwest, 2022)Biocatalysis is the use of nature’s biological catalysts – “enzymes” to perform synthetic chemical reactions, which are generally “greener” than traditional chemical methods. Laccases are a group of oxidoreductase enzymes ... -
A novel approach to analytical mineral analysis in the diagnosis of animal health.
Larkin, Andrew; Reidy, Sean; Mannion, Celine (Athlone Institute of Technology, 2020-06)Minerals are nutrients that are essential for maintaining biological life. In animals they perform structural, physiological, catalytic and regulatory function. However when mineral deficiencies or toxicities occur ... -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.
Carolan, Ciaran G.; Gaynor, Joanne M.; Dillon, Gerry P.; Khan, Denise; Ryder, Sheila A.; Reidy, Sean; Gilmer, John F. (Elsevier, 2008-09-25)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
Quantification of select minerals in animal serum and vitreous humour by inductively coupled plasma - optical emission spectrometry - ICP-OES
Larkin, Andrew; Reidy, Sean; Mannion, Celine (Athlone Institute of Technology/Department of Agriculture, Food and the Marine, 2020-05)Mineral intake and balances are essential in maintaining good animal health and wellbeing. Mineral deficiencies and toxicities can have a detrimental impact on animal health. Important to diagnose these occurrences ...