Browsing Technological University of the Shannon: Midlands Midwest by Author "MacHugh, David E."
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Alveolar macrophage chromatic is modified to orchestrate host response to Mycobacterium bovis infection.
Hall, Thomas J.; Vernimmen, Douglas; Browne, John A.; Mullen, Michael P.; Gordon, Stephen V.; MacHugh, David E.; O'Doherty, Alan M. (Frontiers, 2019-02-07)Bovine tuberculosis is caused by infection with Mycobacteriumbovis, which can also cause disease in a range of other mammals, including humans. Alveolar macrophages are the key immune effector cells that first encounter ... -
DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.
Magee, David A.; Sikora, Klaudia M.; Berowicz, Erik W.; Berry, Donagh P.; Howard, Dawn J.; Mullen, Michael P.; Evans, Ross D.; Spillane, Charles; MacHugh, David E. (BMC, 2010-10-13)Background: Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian ... -
DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits
Kikora, Klaudia M.; Magee, David A.; Berkowicz, Erik W.; Berry, Donagh P.; Howard, Dawn; Mullen, Michael P.; Evans, Ross D.; MacHugh, David E.; Spillane, Charles (BMC, 2011-01-11)Background: Genes which are epigenetically regulated via genomic imprinting can be potential targets for artificial selection during animal breeding. Indeed, imprinted loci have been shown to underlie some important ... -
Estimating the frequency of genomic polymorphisms associated with meat quality in Irish beef cattle
Quigley, Katie; O'Kane, Lyndsey; Kearney, Francis; Hall, Thomas J.; MacHugh, David E.; Mullen, Michael P. (Athlone Institute of Technology, 2020-06)The calpain (CAPN) and calpastatin (CAST) genes play significant roles in meat tenderness (Casas et al., 2005). Identification and estimation of the frequency of DNA mutations involved in meat tenderness would not only ... -
Integrative genomics of the mammalian alveolar macrophage response to intraceullular mycobacteria
Hall, Thomas J.; Mullen, Michael P.; McHugo, Gillian; Killick, Kate E.; Ring, Siobhán C.; Berry, Donagh P.; Correia, Carolina N.; Browne, John A.; Gordon, Stephen V.; MacHugh, David E. (BMC, 2021)Bovine TB (bTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production. The key innate immune cell that first encounters the pathogen is the alveolar macrophage, ... -
Polymorphism discovery and allele frequency estimation using high-throughput DNA sequencing of target-enriched pooled DNA samples
Mullen, Michael P.; Creevey, Christopher J.; Berry, Donagh P.; McCabe, Matt S.; Magee, David A.; Howard, Dawn J.; Killeen, Aideen P.; Park, Stephen D.; McGettigan, Paul A.; Lucy, Matt C.; MacHugh, David E.; Waters, Sinead M. (BMC, 2012-01-11)Background: The central role of the somatotrophic axis in animal post-natal growth, development and fertility is well established. Therefore, the identification of genetic variants affecting quantitative traits within ... -
A population genomics analysis of the native Irish Galway sheep breed.
McHugo, Gillian; Browett, Sam; Randhawa, Imtiaz A. S.; Howard, Dawn; Mullen, Michael P.; Richardson, Ian W.; Park, Stephen D. E.; Magee, David A.; Scraggs, Erik; Dover, Michael J.; Correia, Carolina N.; Hanrahan, James P.; MacHugh, David E. (Frontiers Media, 2019-10)The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as ‘at-risk’. In the present study, comparative population genomics analyses of Galway sheep ...