Browsing Technological University of the Shannon: Midlands Midwest by Author "Lyons, John G."
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3D printed end of arm tooling (EOAT) for robotic automation.
Jing, Daniel Ong U.; Devine, Declan M.; Lyons, John G. (MDPI, 2018-09)This research furthers the practice of designing and manufacturing End of Arm Tooling (EOAT) by utilizing a low cost additive manufacturing Fused Filament Fabrication (FFF) technique to enable tool weight saving and ... -
Additive manufacturing of personalized pharmaceutical dosage forms via stereolithography.
Healy, Andrew V.; Fuenmayor, Evert; Doran, Patrick; Geever, Luke M.; Higginbotham, Clement L.; Lyons, John G. (MDPI, 2019-12-03)The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug ... -
Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets.
Fuenmayor, Evert; Forde, Martin; Healy, Andrew V.; Devine, Declan M.; Lyons, John G.; McConville, Christopher; Major, Ian (Elsevier, 2019-03-10)Oral tablets are a convenient form to deliver active pharmaceutical ingredients (API) and have a high level of acceptance from clinicians and patients. There is a wide range of excipients available for the fabrication of ... -
Degradable nanocomposites for fused filament fabrication applications.
Healy, Andrew V.; Waldron, Cathal; Geever, Luke M.; Devine, Declan M.; Lyons, John G. (MDPI, 2018-05-09)There has been a substantial increase in the use and development of plastics over the last century. However, due to ever-diminishing petroleum feedstocks and growing concern for the environment, there has been a rise in ... -
Degradable polymer nanocomposites for fused filament fabrication applications
Healy, Andrew V.; Geever, Luke M.; Devine, Declan M.; Lyons, John G. (Athlone Institute of Technology, 2018-04-24)The use of plastics in everyday life has increased dramatically during the course of the 20th and 21st century which is primarily due to the characteristics plastics offer in the development of new products to meet the ... -
The development of advanced smart polymer formulations for potential biomedical applications.
Halligan, Shane C. (Athlone Institute of Technology, 2020-10)In the past twenty years, a theme in the pharmaceutical industry is to move towards more efficient use of active pharmaceutical ingredients and the need for improved delivery systems. Smart polymers throughout the literature ... -
Development of high strength nanocomposite for biodegradable stents
Venkatesh, Chaitra; Chen, Yuanyuan; Cao, Zhi; Brennan, Shane; Major, Ian; Lyons, John G.; Devine, Declan M. (Athlone Institute of Technology, 2018-04-24)The use of biodegradable polymer materials are considered to be good alternatives in urology (Donohue et. al. 2018), cardiovascular (Brie et. al. 2016) and tracheal airway stenosis which provide support before it is absorbed ... -
Development of novel monolithic matrices for drug delivery using conventional and non-conventional polymer processing technologies.
Lyons, John G. (2007)The aim of this study was to produce a range of polymer based monolithic matrices for controlled oral drug delivery using conventional polymer processing equipment. Poly (ethylene oxide) (PEO) was chosen as the primary ... -
The effect of cooling on the degree of crystallinity, solid-state properties, and dissolution rate of multi-component hot-melt extruded solid dispersions.
Hurley, Dean; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (MDPI, 2020-03-01)The effect of cooling on the degree of crystallinity, solid-state and dissolution properties of multi-component hot-melt extruded solid dispersions [SD] is of great interest for the successful formulation of amorphous ... -
Faster release of lumen-loaded drugs than matrix-loaded equivalent in polylactic acid/halloysite nanotubes.
Venkatesh, Chaitra; Clear, Oran; Lyons, John G.; Devine, Declan M.; Faster release of lumen (MDPI, 2019-06-15)Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based ... -
Fused-filament fabrication of PEEK: a review of process-structure-property relationships.
Zanjanijam, Ali Reza; Major, Ian; Lyons, John G.; Lafont, Ugo; Devine, Declan M. (MDPI, 2020-07-27)Poly (ether ether ketone) (PEEK) is a high-performance engineering thermoplastic polymer with potential for use in a variety of metal replacement applications due to its high strength to weight ratio. This combination ... -
Halloysite nanotube reinforced polylactic acid composite.
Chen, Yuanyuan; Geever, Luke M.; Killion, John; Lyons, John G.; Higginbotham, Clement L. (Wiley, 2017-10)Polylactic acid (PLA) has long history in medical applications, and reinforced PLA has the potential to be used in the medical applications that require high mechanical strength such as coronary stents and bone fixation ... -
Heat dissipation plays critical role for longevity of polymer-based 3D-printed inserts for plastics injection moulding.
Moritz, Vicente; Bezerra, Gilberto S.N.; Hopkins, Michael Jnr.; Fuenmayor, Evert; Günbay, Suzan; Hayes, Conor; Lyons, John G.; Devine, Declan M. (MDPI, 2022-10-08)Injection moulding is a polymer processing method of choice for making plastic parts on industrial scale, but its traditional mould is made from tooling steel with time-consuming and costly production. Additive manufacturing ... -
Influence of annealing and biaxial expansion on the properties of Poly-l-lactic) medical tubing.
Dillon, Brian; Doran, Patrick; Fuenmayor, Evert; Healy, Andrew V.; Gately, Noel M.; Major, Ian; Lyons, John G. (MDPI, 2019-07-11)Poly-l-lactic acid (PLLA) is one of the most common bioabsorbable materials in the medical device field. However, its use in load-bearing applications is limited due to its inferior mechanical properties when compared ... -
Influence of extrusion screw speed on the properties of halloysite nanotube impregnated polylactic acid nanocomposites
Venkatesh, Chaitra; Chen, Yuanyuan; Cao, Zhi; Brennan, Shnae; Major, Ian; Lyons, John G.; Devine, Declan M. (De Gruyter, 2021)Poly (lactic acid)/halloysite nanotube (PLA/HNT) nanocomposites have been studiedextensively over the past fewyears owing to the interesting properties of the polymer, PLA, and the nanoclay, HNT, individually and as ... -
The influence of low shear microbore extrusion on the properties of high molecular weight poly(l-lactic acid) for medical tubing applications.
Dillon, Brian; Doran, Patrick; Fuenmayor, Evert; Healy, Andrew V.; Gately, Noel M.; Major, Ian; Lyons, John G. (MDPI, 2019-04)Biodegradable polymers play a crucial role in the medical device field, with a broad range of applications such as suturing, drug delivery, tissue engineering, sca olding, orthopaedics, and fixation devices. Poly-l-lactic ... -
Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate).
Pezzoli, Romina; Lyons, John G.; Gatley, Noel; Higginbotham, Clement L. (Elsevier, 2018)The investigation of the miscibility between active pharmaceutical ingredients (API’s) and polymeric excipients is of great interest for the formulation and development of amorphous solid dispersions, especially in the ... -
An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed Copovidone hot-melt extruded solid dispersions.
Hurley, Dean; Carter, David; Ng, Lawrence Yee Foong; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (Elsevier, 2019-10)Previous research has focused on spray dried quaternary mixtures which due to the addition of a surfactant 26 affected the physical stability and amorphous stability of selected model drugs. Very little research has 27 ... -
Mass-customization of oral tablets via the combination of 3D printing and injection molding.
Fuenmayor, Evert; O'Donnell, Crevan; Gately, Noel; Doran, Patrick; Devine, Declan M.; Lyons, John G.; McConville, Christopher; Major, Ian (Elsevier, 2019-10-05)The new frontier of medicine is the personalization of treatment to match a patient’s individual needs. Fused-filament fabrication (FFF) offers a platform for the personalization of drug dosage forms, but one of its chief ... -
Material considerations for fused-filament fabrication of solid dosage forms.
Fuenmayor, Evert; Forde, Martin; Healy, Andrew V.; Devine, Declan M.; Lyons, John G.; McConville, Christopher; Major, Ian (MDPI, 2018-04)Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, ...