Browsing Technological University of the Shannon: Midlands Midwest by Author "Kealey, Carmel"
Now showing items 1-13 of 13
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Application of biomaterials for complex anal fistulae
Fitzpatrick, Daniel P.; Kealey, Carmel; Brady, Damien; Gately, Noel (Taylor & Francis, 2021-11-07)Complex anal fistulae remain a challenge for the medical sector as conventional treatments put patients at risk of incontinence. Clinicians and researchers have become interested in the application of bioresorbable ... -
Comparative activity of silver based antimicrobial composites for urinary catheters.
Thokala, Nikhil; Kealey, Carmel; Kennedy, James; Brady, Damien B.; Farrell, Joseph (Elsevier, 2018-08-18)Biomedical polymers are an integral component in a wide range of medical devices because of their many desirable properties. However, extensive use of polymer materials in medical devices has been associated with an ... -
Development of dental implants with antimicrobial activity
Mulry, Aoife; Kealey, Carmel; Brady, Damien; Gately, Noel (Technological University of the Shannon Midlands Midwest, 2022)Planktonic bacteria are capable of forming biofilms, which are described as microbial aggregates embedded within a matrix of extracellular polymeric substances (EPS) and are found attached to abiotic or biotic surfaces ... -
The development of novel bioresorbable medical devices for treating diseases of the anal canal
Fitzpatrick, Daniel P.; Brady, Damien; Kealey, Carmel; Gatley, Noel (Athlone Institute of Technology, 2020-06)Anal abscesses and fistulae in ano are the most prominent diseases of the anal canal Abscesses are pockets of pus caused by accumulating bactera whereas fistulae in ano are hollow tunnels that protrude from the wall of ... -
Evaluation of vegetable oils and their respective fatty acids on the viability of streptococcus mutans, a presistent oral pathogen.
Hughes, P.I.; Kealey, Carmel; Rowan, Neil J.; Brady, Damien B. (AESS, 2013-06)This study evaluated the in vitro antibacterial activity of vegetable oils and their respective fatty acid constituents on the growth of Streptococcus mutans. S. mutans is one of the primary etiological agents associated ... -
Fingerprinting critical therapeutic attributes: overcoming challenges to fulfil commercial potential – Early stages
Lawler, Grace; Roche, Jim; Brady, Damien; Kealey, Carmel (Technological University of the Shannon Midlands Midwest, 2022)Aim: This research endeavour will determine and evaluate the mechanism of action of a modified coconut oil that has previously shown promising antimicrobial activity against the opportunistic infection, T. rubrum. Background: ... -
Influence of reconstitution temperature on survival of Cronobacter Sakazakii in powdered infant formula.
McEvoy, Kelsey C.; Kealey, Carmel; Brady, Damien B. (Slovak University of Agriculture in Nitra. Faculty of Biotechnology and Food Sciences., 2016-04)Cronobacter spp. are emerging opportunistic pathogens commonly associated with the feeding of powdered infant formula (PIF). This study aimed to investigate the ability of C.sakazakii (ATCC 29544) to survive heat injury ... -
Insights into the mechanisms of Cronobacter sakazakii virulence
Phair, Katie; Gonçalves Pereira, Sónia; Kealey, Carmel; Fanning, Séamus; Brady, Damien B. (Elsevier, 2022-06)Cronobacter species have adapted to survive harsh conditions, particularly in the food manufacture environment, and can cause life-threatening infections in susceptible hosts. These opportunistic pathogens employ a multitude ... -
An investigation of the in vitro effects of unconjugated linoleic acid and its potential impact on haemostasis
Kielty, Catriona (Athlone Institute of Technology, 2021-04)Introduction: Linoleic acid, an essential ω6 fatty acid, is the most abundant polyunsaturated fatty acid in the Western mammalian diet. Linoleic acid has been linked with an increased inflammatory response. It has also ... -
A laboratory investigation of the antimicrobial activity of a selection of western phytomedicinal tinctures.
Coss, Emily; Kealey, Carmel; Brady, Damien; Walsh, Patrick (Elsevier, 2018-04)Introduction: Following the observed success of a herbal cocktail in controlling and eliminating acute respiratory infections in a group of approximately sixty, 1–3 year old equines, it was decided to test ten of the herbs ... -
A risk assessment-based control strategy to formulate a potent, efficacious, and non-invasive topical onychomycotic dosage form
Kapu, Dinesh (Technological University of the Shannon: Midlands Midwest, 2021)This project involves the development of a strategy to formulate a novel dosage form with modified coconut oil (MCO) as the active pharmaceutical ingredient to treat onychomycosis caused by T. rubrum and C. albicans. ... -
The toxicological impact of unconjugated linoleic acid
Kielty, Catriona; Brady, Damien; Kealey, Carmel (Athlone Institute of Technology, 2018-04-24)Linoleic acid, an omega-6 polyunsaturated fatty acid, is one of the most abundant fatty acids in the Western diet (Whelan, 2008). Linoleic acid, being a precursor for arachidonic acid, is associated with the production of ... -
Treatment for the amelioration of persistent factors in complex anal fistula
Fitzpatrick, Daniel P.; Kealey, Carmel; Brady, Damien; Goodman, Martin; Gately, Noel (Springer, 2021-11-19)Anal fistulae are abnormal hollow connections between the wall of the anal canal and the perianal skin around the anus that have remained a burden on the medical sector for centuries. The complexity of this disease is ...