Browsing Technological University of the Shannon: Midlands Midwest by Author "Hall, Thomas J."
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Alveolar macrophage chromatic is modified to orchestrate host response to Mycobacterium bovis infection.
Hall, Thomas J.; Vernimmen, Douglas; Browne, John A.; Mullen, Michael P.; Gordon, Stephen V.; MacHugh, David E.; O'Doherty, Alan M. (Frontiers, 2019-02-07)Bovine tuberculosis is caused by infection with Mycobacteriumbovis, which can also cause disease in a range of other mammals, including humans. Alveolar macrophages are the key immune effector cells that first encounter ... -
Estimating the frequency of genomic polymorphisms associated with meat quality in Irish beef cattle
Quigley, Katie; O'Kane, Lyndsey; Kearney, Francis; Hall, Thomas J.; MacHugh, David E.; Mullen, Michael P. (Athlone Institute of Technology, 2020-06)The calpain (CAPN) and calpastatin (CAST) genes play significant roles in meat tenderness (Casas et al., 2005). Identification and estimation of the frequency of DNA mutations involved in meat tenderness would not only ... -
Integrative genomics of the mammalian alveolar macrophage response to intraceullular mycobacteria
Hall, Thomas J.; Mullen, Michael P.; McHugo, Gillian; Killick, Kate E.; Ring, Siobhán C.; Berry, Donagh P.; Correia, Carolina N.; Browne, John A.; Gordon, Stephen V.; MacHugh, David E. (BMC, 2021)Bovine TB (bTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production. The key innate immune cell that first encounters the pathogen is the alveolar macrophage, ...