Now showing items 1-2 of 2

    • Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. 

      Dillon, Gerald P.; Gaynor, Joanne M.; Khan, Denise; Carolan, Ciaran G.; Ryder, Sheila A.; Marquez, Juan F.; Reidy, Sean; Gilmer, John F. (Elsevier, 2010-02-01)
      Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer’s Disease (AD). They are stable in human plasma but in mouse plasma they ...
    • Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase. 

      Carolan, Ciaran G.; Gaynor, Joanne M.; Dillon, Gerry P.; Khan, Denise; Ryder, Sheila A.; Reidy, Sean; Gilmer, John F. (Elsevier, 2008-09-25)
      We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC, are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ...