Browsing Technological University of the Shannon: Midlands Midwest by Author "Gatley, Noel"
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The development of novel bioresorbable medical devices for treating diseases of the anal canal
Fitzpatrick, Daniel P.; Brady, Damien; Kealey, Carmel; Gatley, Noel (Athlone Institute of Technology, 2020-06)Anal abscesses and fistulae in ano are the most prominent diseases of the anal canal Abscesses are pockets of pus caused by accumulating bactera whereas fistulae in ano are hollow tunnels that protrude from the wall of ... -
Enhancing drug solubility through advanced polymer extruded shellac-based matrix drug delivery systems
Yan, Guangming (Technological University of the Shannon: Midlands Midwest, 2022-09)The main objective of this study is to enhance the solubility of the model drug fenofibrate, by forming amorphous solid dispersions using a hot melt extrusion process. Hot melt extrusion offers an efficient way of ... -
Investigation of miscibility estimation methods between indomethacin and poly(vinylpyrrolidone-co-vinyl acetate).
Pezzoli, Romina; Lyons, John G.; Gatley, Noel; Higginbotham, Clement L. (Elsevier, 2018)The investigation of the miscibility between active pharmaceutical ingredients (API’s) and polymeric excipients is of great interest for the formulation and development of amorphous solid dispersions, especially in the ... -
Micro-injection moulding of poly(vinylpyrrolidone-vinyl acetate) binary and ternary amorphous solid dispersions.
Pezzoli, Romina; Hopkins, Michael Jnr.; Direur, Guillaume; Gatley, Noel; Lyons, John G.; Higginbotham, Clement L. (MDPI, 2019-05)Micro-injection moulding (µIM) was used for the production of enteric tablets of plasticised and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect of the mechanical and thermal ... -
"My heart, your heart"; hot melt enteric targeted therapeutic delivery platform: enhancing drug solubility through advanced polymer extruded drug delivery system
Yan, Guangming; Cao, Zhi; Devine, Declan; Gatley, Noel (Athlone Institute of Technology, 2020-06)Cardiovascular diseases (CVDs) are the number 1 cause of death globally. Fenofibrate has been shown an excellent treating effect on CVDs. However, Fenofibrate is a neutral, lipophilic compound that is practically insoluble ... -
Stability studies of hot-melt extruded ternary solid dispersions of poorly-water soluble Indomethacin with Poly(vinyl pyrrolidone-co-vinyl acetate) and polyethylene oxide.
Pezzoli, Romina; Lyons, John G.; Gatley, Noel; Higginbotham, Clement L. (Elsevier, 2019-08)This investigation aims to evaluate the effect of moisture and temperature on the physical stability and dissolution behaviour of hot-melt extruded binary and plasticised ternary solid dispersions. Poorly water-soluble ...