Others - Other Research areashttps://research.thea.ie/handle/20.500.12065/24922024-03-28T08:19:30Z2024-03-28T08:19:30ZCould inversion improve your decision-making?Dwyer, Christopherhttps://research.thea.ie/handle/20.500.12065/46892023-12-01T03:01:50Z2023-07-27T00:00:00ZCould inversion improve your decision-making?
Dwyer, Christopher
Inversion thinking asks us to mentally simulate a scenario in which our answer/solution is incorrect.
Working backward, like reverse engineering, is a common method used in problem-solving.
Considering what makes a hypothetical answer "bad" may help generate ideas for what might be improved.
2023-07-27T00:00:00ZApprenticeship Strategic Implementation Planhttps://research.thea.ie/handle/20.500.12065/46472023-11-04T03:02:03Z2023-06-16T00:00:00ZApprenticeship Strategic Implementation Plan
The vision of the Technological University
of the Shannon: Midlands Midwest (TUS)
Strategic Plan 2023 – 2026, is to be a
catalyst for sustainable change through
education and research that transforms
lives, in the Midlands and Midwest regions
and the world beyond. The Department of
Further and Higher Education, Research,
Innovation and Science (DFHERIS) Action
Plan for Apprenticeship, 2021–2025 sets
out to reimagine the apprenticeship system
in Ireland and to recreate one that is flexible
and responsive, providing a strong value
proposition for employers and potential
apprentices, is attractive and easy to
engage with, and delivers high standards
and sought after qualifications. This
Apprenticeship Strategic Implementation
Plan lays out the ways and means through
which TUS will be an active participant in,
and contribute to, the DFHERIS Action Plan
for Apprenticeship through the vision and
priorities of the university Strategic Plan.
This articulates the TUS commitment to the
apprenticeship model of education and the
vision of our Technological University for
playing a leading role in the delivery of the
Action Plan for Apprenticeships through
the prism of the TUS Strategic Plan.
2023-06-16T00:00:00ZIn vitro Antitrypanosomal Activities of the stem bark of Entadrophragma angolense (Meliaceae)Adams, LatifMoane, SiobhanObiri-Yeboah, DorcasMcKeon-Bennett, Michellehttps://research.thea.ie/handle/20.500.12065/46462023-11-04T03:00:23Z2023-01-01T00:00:00ZIn vitro Antitrypanosomal Activities of the stem bark of Entadrophragma angolense (Meliaceae)
Adams, Latif; Moane, Siobhan; Obiri-Yeboah, Dorcas; McKeon-Bennett, Michelle
African
Trypanosomiasis continues to be a major public health
concern worldwide, especially in developing countries with
thousands of new infected cases yearly 1 They are
associated with high significant morbidity and large economic
impacts Currently, there are no vaccines to combat this
disease, and current chemotherapy regimens are highly toxic,
ineffective, and resistant Hence, novel and potent
trypanocides are urgently needed Medicinal plants have been
documented to be a potential source for the development of
antitrypanosomal compounds Amongst such is
Entadrophragma angolense an ethnopharmacological plant
used in West Africa to treat several ailments including
protozoan diseases 2 In this present study, we investigated
the potential antitrypanosomal properties of E angolense and
its possible development as a therapeutic intervention for
treating African trypanosomiasis In vitro effects of crude
extracts and fractions of stem bark of E angolense were tested
against Trypanosoma brucei using Alamar blue assay
Additionally, the crude extract’s antioxidant (FRAP and
DPPH) and cytotoxicity activities were also determined The
phytochemical profiling of the crude extract was determined
using LC ESI QTOF MS to identify major bioactive
compounds present Bioactive compounds identified were
subjected to molecular docking studies.
2023-01-01T00:00:00ZIn vitro Antitrypanosomal, Antioxidant and Cytotoxicity Activities, LC MS analysis and Molecular docking analysis of bioactive compounds from Anopyxis klaineana against UDP Galactose 4` Epimerase (GalE) of Trypanosoma bruceiAdams, LatifObiri-Yeboah, DorcasMcKeon-Bennett, MichelleMoane, Siobhanhttps://research.thea.ie/handle/20.500.12065/46452023-11-04T03:01:53Z2023-01-01T00:00:00ZIn vitro Antitrypanosomal, Antioxidant and Cytotoxicity Activities, LC MS analysis and Molecular docking analysis of bioactive compounds from Anopyxis klaineana against UDP Galactose 4` Epimerase (GalE) of Trypanosoma brucei
Adams, Latif; Obiri-Yeboah, Dorcas; McKeon-Bennett, Michelle; Moane, Siobhan
African
Trypanosomiasis is a major public health concern worldwide, especially in developing countries 1 Current chemotherapies are highly toxic, resistant and ineffective
Hence, novel effective and potent trypanocides are needed Medicinal plants have been documented to be a potential source for the development of antitrypanosomal
compounds Anopyxis klaineana is an ethnomedicinal plant used in west Africa to treat many ailments including protozoan diseases In this study, we investigated the in vitro
effects of crude methanol extracts and fractions of A klaineana for their antitrypanosomal activities against Trypanosoma brucei using Alamar blue assay Additionally, the crude
extract’s antioxidant and cytotoxicity activities were also determined The phytochemical profiling of the crude extract was determined using LC ESI QTOF MS to identify major
bioactive compounds present Bioactive compounds identified were subjected to molecular docking studies against Trypanosoma brucei’s UDP Galactose 4 Epimerase (TbGalE
2023-01-01T00:00:00Z